Hepatotoxicity Assessment of Stem Bark Extract of Acacia nilotica in Alloxan Induced Diabetic Rats
Published: 2022-09-05
Page: 59-62
Issue: 2022 - Volume 4 [Issue 1]
Kabiru Sirajo *
Department of Biochemistry, Sokoto State University, Sokoto, Nigeria.
Zulkallaini Shehu
Department of Biochemistry, Sokoto State University, Sokoto, Nigeria.
Ibrahim Mas’ud
Department of Environmental Science, Islamic University in Uganda, Uganda.
Khadijah Almustapha Usman
Department of Biochemistry, Sokoto State University, Sokoto, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Aims: This research work aimed to determine the effect of methanolic Acacia nolitica stem bark extract on liver functions in alloxan induced diabetic rats.
Methodology: Thirty (30) young albino rats were grouped into six (6), comprising of five (5) rats per group. Diabetes was induced by single intraperitoneal injection of freshly prepared alloxan monohydrate and blood glucose level was determined forty eight hours (48 hrs) after injection. After induction of diabetes, Metformin and selected doses of Acacia nolitica stem bark extract were orally administered for 4 weeks after which serum biochemical markers were determined.
Results: Highest hypoglycemic effect was observed at 600mg/kg dose. Total Protein and Albumin were slightly elevated in extract treated groups compared to diabetic untreated group while serum bilirubin decreased. There was decrease in the serum level of ALT, ALP and AST in a dose dependent manner.
Conclusion: Convincingly, the plant extract may exert not only hypoglycemic effect but also hepatic protective effect.
Keywords: Acacia nilotic, alloxan, biochemical markers, diabetic rat, hypoglycemic, metformin